Keesler Air Force Base (IATA: BIX, ICAO: KBIX, FAA LID: BIX) is a United States Air Force base located in Biloxi, a city in Harrison County, Mississippi, United States. The base is named in honor of aviator 2d Lt Samuel Reeves Keesler, Jr., a Mississippi native killed in France during the First World War. The base is home of Headquarters, Second Air Force (2 AF) and the 81st Training Wing (81 TW) of the Air Education and Training Command (AETC).

The base has specialised in ground trade training since its opening in 1941.