Altus Air Force Base (AAFB) (IATA: LTS, ICAO: KLTS, FAA LID: LTS) is a United States Air Force base located approximately 4 miles (6.4 km) east-northeast of Altus, Oklahoma.

The host unit at Altus AFB is the 97th Air Mobility Wing (97 AMW), assigned to the Nineteenth Air Force (19 AF) of the Air Education and Training Command (AETC). The wing's mission is to provide C-17 Globemaster III and KC-135 Stratotanker formal initial and advanced specialty training programs for up to 3000 flight crew and aircraft maintenance students annually.

Altus AFB was established in 1943 as Altus Army Airfield (AAF). The 97 AMW commander is Colonel Todd A. Hohn. The Command Chief Master Sergeant is Chief Master Sergeant Philip E. Eckenrod Jr.